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Research Scientist, Protein Engineer, Global Biologics

Company: Takeda Pharmaceutical
Location: Mount Vernon
Posted on: January 15, 2022

Job Description:

By clicking the -Apply - button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda 's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Scientist, Protein Engineer, Global Biologics in our Cambridge, MA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.POSITION OBJECTIVES:Takeda is committed to the long-term strategy and vision to translate science into life-changing medicines that make important differences for our patients around the world. The Global Biologics team within R&D consists of approximately 85 scientists across two US sites (Cambridge, MA and San Diego, CA), and aims to discover novel therapeutic large molecule biologics serving our four main therapeutic areas Oncology, Gastroenterology, Neuroscience and Rare Disease.We are excited to pursue the search for a Research Scientist to join our Biotherapeutic Engineering team, a group within Takeda's Global Biologics Department. You will join a team of motivated and enthusiastic scientists in the Cambridge, MA location, reporting to the Associate Director, Biotherapeutic Engineering, Global Biologics. You will implement workflows tailored towards protein engineering, primarily enzymes. You will be directly involved in protein engineering from design and build of mutant libraries through to high throughput screening and characterization of candidates. You will be flexible, leading different aspects throughout the protein engineering workflow, and working with team members to ensure smooth coordination of activities.POSITION ACCOUNTABILITIES:

  • Design optimization libraries using in silico tools, followed by manipulation of the plasmid-based DNA libraries.
  • Use display-based systems (yeast, phage) and screening to identify improved mutant proteins.
  • Evaluate and analyze protein sequence, mutational libraries using state-of-the-art sequence analysis software.
  • Plan and execute appropriate in vitro experiments to optimize and characterize libraries.
  • Coordinate with team members to perform high throughput plate-based production and purification of protein from yeast, mammalian cells and bacteria.
  • Help guide and implement workflows and infrastructure tailored to protein or enzyme engineering.
  • Maintain, propagate and transform yeast, mammalian and bacterial cultures.
  • Basic characterization of purified proteins using standard techniques, such as SDS-PAGE.
  • Manage and run automation, in addition to manual steps throughout the process.
  • Demonstrate high organization capabilities to ensure excellent tracking of ongoing and incoming targets and projects.
  • Work with project team leads to develop project strategies and to coordinate work within Global biologics.
  • Upload and track data into data management systems and maintain detailed electronic notebook.
  • Work with a fast pace to meet program and team needs.
  • Experience demonstrating analytical skills, bench skills and problem-solving skills.EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
    • PhD (2+y experience), or MS (8+ years' experience) in Molecular Biology, Protein Engineering, Biochemistry or similar.
    • Experience with protein engineering and standard mutagenesis approaches is preferred.
    • Demonstrated experience in protein production in mammalian or prokaryotic systems.
    • Highly skilled in standard molecular biology techniques and cell culture techniques (yeast, bacterial, mammalian).
    • Experience in protein production and purification is preferred.
    • Experience with high throughput workflows and automation.
    • Experience working with and troubleshooting automation and liquid handling is a plus.
    • Effective resource and time management is essential.
    • Identifies, plans and executes novel scientific projects and may manage the work of others a direct or matrixed structure.
    • Effective oral and written communication as well as strong interpersonal skills required.
    • Hard working, enthusiastic, self-motivated, team oriented with a strong collaborative spirit.WHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsEmpowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.This job posting excludes CO applicants.Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Union City , Research Scientist, Protein Engineer, Global Biologics, Engineering , Mount Vernon, New Jersey

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